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Within industrial process development, powerful screening techniques are required to select the optimal biocatalyst regarding such process characteristics as cost effectivenes (…)

Authors: Rachinskiy, Kirill; Kunze, Martin; Graf, Careen; Schultze, Hergen; Boy, Matthias; Buechs, Jochen

Journal: Biotechnology and Bioengineering, Volume: 111, Issue: 2, Pages: 244-253

BACKGROUND
The oxygen transfer rate (OTR) and the biomass concentration are two important parameters describing a microbial fermentation. It has been shown before that (…)

Authors: Muehlmann, Martina Julia; Forsten, Eva; Noack, Saskia; Buechs, Jochen

Journal: Biotechnology Progress, Volume: 34, Issue: 6, Pages: 1543-1552

CO2 and O2 in the Sakaguchi flask headspace during culture was monitored via circulation direct monitoring and sampling system (CDMSS), a device with circulation bypass system (…)

Authors: Takahashi, Masato; Aoyagi, Hideki

Journal: Applied Microbiology and Biotechnology, Volume: 102, Issue: 15, Pages: 6637-6645

BACKGROUND
Pectin is a rather complex and highly branched polysaccharide strengthening the plant cell wall. Thus, many different pectinases are required for an efficien (…)

Authors: Müller, Markus Jan; Stachurski, Sarah; Stoffels Peter; Schipper, Kerstin; Feldbrügge, Michael; Büchs, Jochen

Journal: Journal of Biological Engineering

Escherichia coli is commonly used for recombinant protein production with many available host strains. Screening experiments are often performed in batch mode using shake flas (…)

Authors: Ihling, Nina; Bittner, Natalie; Diederichs, Sylvia; Schelden, Maximilian; Korona, Anna; Hoefler, Georg Theo; Fulton, Alexander; Jaeger, Karl-Erich; Honda, Kohsuke; Ohtake, Hisao

Journal: Biotechnology Progress, Volume: 34, Issue: 2, Pages: 315-327

BACKGROUND
In Streptomyces, understanding the switch from primary to secondary metabolism is important for maximizing the production of secondary metabolites such as an (…)

Authors: Gamboa-Suasnavart, Ramses A.; Valdez-Cruz, Norma A.; Gaytan-Ortega, Gerardo; Reynoso-Cereceda, Greta I.; Cabrera-Santos, Daniel; Lopez-Griego, Lorena; Kloeckner, Wolf; Buechs, Jochen; Trujillo-Roldan, Mauricio A.

Journal: Microbial Cell Factories,Volume: 17,Article Number: 189

Orbitally shaken bioreactors (OSRs) is one of important bioreactors for mammalian cells cultivation in suspension, especially for the screening of valuable microorganisms and (…)

Authors: Zhu, Likuan; Song, Boyan; Wang, Zhenlong

Journal: Biotechnology Progress

The manipulation of cellular function, such as the regulation of gene expression, is of great interest to many biotechnological applications and often achieved by the addition (…)

Authors: Kusen, Peter M.; Wandrey, Georg; Krewald, Vera; Holz, Martina; zu Berstenhorst, Sonja Meyer; Buechs, Jochen; Pietruszka, Joerg

Journal: Journal of Biotechnology, Volume: 258, Pages: 117-125

BACKGROUND
Escherichia coli is often used for recombinant protein production. The expression of recombinant proteins negatively affects the microbial growth, thus, a ba (…)

Authors: Ladner, Tobias; Muehlmann, Martina; Schulte, Andreas; Wandrey, Georg; Buechs, Jochen

Journal: Journal of Biological Engineering, Volume: 11

In recent years, researchers have explored the application of Reinforcement Learning (RL) and Artificial Neural Networks (ANNs) to the control of complex nonlinear and time va (…)

Authors: Pandian, B. Jaganatha; Noel, Mathew Mithra

Journal: Journal of Process Control (2018), Volume: 69, Pages: 16-29

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